HCID 54328178, compound → HCID 23329104, compound

HRID 225166Notes

Reaction equation

HRID 225166 reaction equation
[CH2:1]([N:8](C)[C:9](=[O:25])[CH2:10][CH2:11][C:12]([C:14]1[CH:19]=[CH:18][C:17]([Cl:20])=[C:16]([S:21](=[O:24])(=[O:23])[NH2:22])[CH:15]=1)=[O:13])C1C=CC=CC=1.[H][H]>CO.[Pd]>[Cl:20][C:17]1[CH:18]=[CH:19][C:14]([C:12]2([OH:13])[N:8]([CH3:1])[C:9](=[O:25])[CH2:10][CH2:11]2)=[CH:15][C:16]=1[S:21](=[O:24])(=[O:23])[NH2:22]

Participants

5

Reactant 2

HCID 54328178HCID 54328178, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 23329104HCID 23329104, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

2 g of 4-(4-chloro-3-sulfamoylphenyl)-4-oxobutanoic acid N-benzyl-N-methylamide are hydrogenated in the presence of 0.5 g of palladium black in 40 ml of methanol in a duck-shaped shaking vessel until the theoretical amount of hydrogen has been taken up, the catalyst is filtered off, the filtrate is concentrated and the residue is worked up analogously to the instructions 1, to give 5-(4-chloro-3-sulfamoylphenyl)-5-hydroxy-1-methyl-2-oxopyrrolidine. Melting point 147°-149° C.

Workup

  1. filtrationthe catalyst is filtered off
  2. concentrationthe filtrate is concentrated

Sources & evidence

ORD record
ord-24a5ec54479a490794c6169f9e97f7d2
Source dataset
uspto-grants-1980_11
Patent number
US04235918

Reaction notes

Loading…