Acetic Anhydride → HCID 23329085, compound

HRID 225167Notes

Reaction equation

HRID 225167 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:14])[CH2:9][CH2:10][C:11](O)=O)=[CH:4][C:3]=1[S:15]([N:18]1[CH2:22][CH2:21][CH2:20][CH2:19]1)(=[O:17])=[O:16].C(OC(=O)C)(=[O:25])C>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][CH2:10][C:11](=[O:25])[CH:14]=2)=[CH:4][C:3]=1[S:15]([N:18]1[CH2:22][CH2:21][CH2:20][CH2:19]1)(=[O:17])=[O:16]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 23329091HCID 23329091, compound

Product 1

HCID 23329085HCID 23329085, compound

Procedure

3.9 g of 4-[4-chloro-3-(1-pyrrolidinylsulfonyl)-phenyl]-4-oxobutanoic acid are boiled under a reflux condenser in 50 ml of acetic anhydride for 1 hour, the solvent is driven off under reduced pressure and the residue is caused to crystallize under diisopropyl ether. 5-[4-Chloro-3-(1-pyrrolidinylsulfonyl)-phenyl]-2,3-dihydro-3-oxofuran is obtained in the form of light red-colored crystals of melting point 108°-111° C.

Workup

  1. customto crystallize under diisopropyl ether

Sources & evidence

ORD record
ord-2cde6ecfb93141929913cbbea08b17d5
Source dataset
uspto-grants-1980_11
Patent number
US04235918

Reaction notes

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