4-Cyanophenylboronic acid → 4-(3,3-dimethyl-1-oxo-2,3-dihydro-1H-inden-5-yl)benzonitrile

HRID 2251688Notes

Reaction equation

HRID 2251688 reaction equation
[CH3:1][C:2]1([CH3:20])[C:10]2[C:5](=[CH:6][CH:7]=[C:8](OS(C(F)(F)F)(=O)=O)[CH:9]=2)[C:4](=[O:19])[CH2:3]1.[C:21]([C:23]1[CH:28]=[CH:27][C:26](B(O)O)=[CH:25][CH:24]=1)#[N:22]>>[CH3:1][C:2]1([CH3:20])[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([C:26]3[CH:27]=[CH:28][C:23]([C:21]#[N:22])=[CH:24][CH:25]=3)[CH:9]=2)[C:4](=[O:19])[CH2:3]1

Participants

3

Reactant 2

HCID 27343264-Cyanophenylboronic acidHCID 57618520Trifluoromethanesulfonic acid 3,3-dimethyl-1-oxo-indan-5-yl ester

Product 1

HCID 690382944-(3,3-dimethyl-1-oxo-2,3-dihydro-1H-inden-5-yl)benzonitrile

Procedure

The title compound was prepared from trifluoro-methanesulfonic acid 3,3-dimethyl-1-oxo-indan-5-yl ester and 4-cyanophenyl boronic acid according to the procedure described in example 21. MS (ESI) m/z 262; HRMS: calcd for C18H15NO+H+, 262.12264; found (ESI, [M+H]+), 262.1237.

Sources & evidence

ORD record
ord-1c49d578f3b84c1cab1d2a26c9c404ca
Source dataset
uspto-grants-2008_01
Patent number
US07319152B2

Reaction notes

Loading…