HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Amino-2-nitrobenzoic acid → 2-Nitro-5-(2,3,5,6-tetrafluoro-4-trifluoromethylbenzylamino)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Amino-2-nitrobenzoic acid | HCID 83298 | — |
| Reactant | 4-(Trifluoromethyl)-2,3,5,6-tetrafluorobenzyl bromide | HCID 127137 | — |
| Product | 2-Nitro-5-(2,3,5,6-tetrafluoro-4-trifluoromethylbenzylamino)benzoic acid | HCID 10251093 | 76.3% |
Reaction Steps
According to the similar procedure in Synthesis Example 1, by using 5-amino-2-nitrobenzoic-acid (1.03 g, 5.65 mmole) and 2,3,5,6-tetrafluoro-4-trifloromethylbenzyl bromide (1.01 g, 6.04 mmole)(ACROS, 33074-0010), 1.50 g (76.3% yield) of 2-nitro-5-(2,3,5,6-tetrafluoro-4-trifluoromethylbenzylamino)benzoic acid was obtained as a pale yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07319160B2 |
| Source dataset | uspto-grants-2008_01 |
| ORD ID | ord-26039a45b67b410faccf45c2e8919863 |
| Source note | uspto-grants-2008_01 |