HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Trifluoromethyl)-2,3,5,6-tetrafluorobenzyl bromide → 2-Methoxy-5-(2,3,5,6-tetrafluoro-4-trifluoromethylbenzylamino)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Trifluoromethyl)-2,3,5,6-tetrafluorobenzyl bromide | HCID 127137 | — |
| Reactant | 5-Amino-2-methoxybenzoic acid | HCID 13549244 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-Methoxy-5-(2,3,5,6-tetrafluoro-4-trifluoromethylbenzylamino)benzoic acid | HCID 10046332 | 31.5% |
Reaction Steps
According to the similar procedure in Synthesis Example 1, by using 5-amino-2-methoxy-benzoic acid (2.10 g, 12.7 mmole), DMF (50 ml), TEA (6 ml), and 2,3,5,6-tetrafluoro-4-trifluoromethylbenzyl bromide (2.00 ml, 14.0 mmole), 1.50 g (31.5% yield) of 2-methoxy-5-(2,3,5,6-tetrafluoro-4-trifluoromethylbenzylamino)benzoic acid was obtained as a yellow solid:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07319160B2 |
| Source dataset | uspto-grants-2008_01 |
| ORD ID | ord-ef57b55275d1455c804bf00d3825e0ff |
| Source note | uspto-grants-2008_01 |