反应详情

Part C: To a stirred suspension of methyl 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-1H-1,2,4-triazole-3-carboxylate (11.3 gram, 0.0295 mol) in methanol (100 mL) is added KOH (45% aqueous solution, 7.5 mL) and the resulting mixture is heated at reflux temperature for 4 hours. The mixture is concentrated in vacuo and water (150 mL) and concentrated HCl are added. The yellow precipitate is collected by filtration, washed with water and dried in vacuo to give 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-1H-1,2,4-triazole-3-carboxylic acid (10.0 gram, 92% yield). Melting point: 141-144° C. (decomposition).

1. temperaturethe resulting mixture is heated
2. temperatureat reflux temperature for 4 hours
3. concentrationThe mixture is concentrated in vacuo and water (150 mL) and concentrated HCl
4. additionare added
5. filtrationThe yellow precipitate is collected by filtration
6. washwashed with water
7. customdried in vacuo