HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 3-(3,5-dibromo-4-hydroxyphenyl)propionate → 3-[3,5-Dibromo-4-(3-hydroxybenzyloxy)phenyl]propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 3-(3,5-dibromo-4-hydroxyphenyl)propionate | HCID 624213 | — |
| Reactant | 3-(Bromomethyl)phenyl acetate | HCID 6422075 | — |
| Product | 3-[3,5-Dibromo-4-(3-hydroxybenzyloxy)phenyl]propionic acid | HCID 22242281 | 78% |
Reaction Steps
Methyl 3-(3,5-dibromo-4-hydroxyphenyl)propionate (0.15 g, 0.44 mmol) was coupled with 3-bromomethylphenyl acetate (0.20 g, 0.88 mmol) using the procedure described in Method D4. Purification on column (silica gel, dichloromethane/methanol, gradient elution from 95:5 to 90:10) gave 123 mg (78%) of 3-[3,5-dibromo-4-(3-hydroxybenzyloxy)phenyl]propionic acid. MS: m/z 430.1 (M+−1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07319163B2 |
| Source dataset | uspto-grants-2008_01 |
| ORD ID | ord-a98de718202d4750a3da571ee76544ba |
| Source note | uspto-grants-2008_01 |