2,2-Dimethoxypropane → HCID 21993607, compound

Participants

Reaction Steps

5 g of (3,4-bis-hydroxymethylphenyl)methanol (29.7 mmol), 25 ml of 2,2-dimethoxypropane (21.2 g; 0.2 mmol) and 0.29 g of p-toluenesulfonic acid (1.5 mmol) are introduced into a flask. After stirring for 1 hour 10 minutes at room temperature, the solvent is evaporated under vacuum at 30° C. and the crude product is chromatographed on silica gel (dichloromethane/methanol/aqueous ammonia=98/2/0.1). 5.98 g of (7,7-dimethyl-(5H,9H)-6,8-dioxabenzocyclohepten-2-yl)methanol are obtained in the form of a white powder.

Provenance & Evidence