4-Toluenesulfonyl chloride → HCID 58880520, compound

Participants

Reaction Steps

1.5 g (5 mmol) of [7-(4-nitrophenyl)-(5H,9H)-6,8-dioxabenzocyclohepten-2-yl]methanol in 15 ml of dichloromethane are introduced into a flask. 0.76 g (7.5 mmol) of triethylamine is added and 1 g (5.4 mmol) of p-toluenesulfonyl chloride is added in small solid portions at room temperature. After 20 hours of reaction, the solvent is evaporated off and the crude product is purified by silica gel chromatography (heptane/ethyl acetate: 4/1) to give 0.6 g of 2-chloromethyl-7-(4-nitrophenyl)-(5H,9H)-6,8-dioxabenzocycloheptene.

Provenance & Evidence