反应详情

A solution of 3-hydroxybenzenesulfonamide (0.5 g, 2.89 mmol) and 1-(3-bromopropoxy)-4-phenoxy-2-propylbenzene (1.01 g, 2.89 mmol) with cesium carbonate (1.04 g, 3.18 mmol) in dry DMF (10 mL) was stirred at 50° C. for 5 h. The reaction suspension was cooled to room temperature and concentrated under vacuum to an orange residue. The residue was partitioned between ethyl acetate and water. The ethyl acetate phase was dried over sodium sulfate, filtered, and concentrated to an oil. The oil was chromatographed over silica gel with hexanes/ethyl acetate (2:1) to provide the title compound.

1. concentrationconcentrated under vacuum to an orange residue
2. customThe residue was partitioned between ethyl acetate and water
3. dry with materialThe ethyl acetate phase was dried over sodium sulfate
4. filtrationfiltered
5. concentrationconcentrated to an oil
6. customThe oil was chromatographed over silica gel with hexanes/ethyl acetate (2:1)