HCID 86586593, compound → HCID 86586592, compound

HRID 2251744Notes

Reaction equation

HRID 2251744 reaction equation
C([O:5][C:6]([C@@H:8]([NH:63][C:64]([C@@H:66]1[C:70]([CH3:72])([CH3:71])[S:69][CH2:68][N:67]1[S:73]([C:76]1[CH:81]=[CH:80][C:79]([CH3:82])=[CH:78][CH:77]=1)(=[O:75])=[O:74])=[O:65])[CH2:9][C:10]1[CH:15]=[CH:14][C:13]([O:16][C:17]([N:19]2[CH2:24][CH2:23][N:22]([C:25]([O:27][C:28]3[CH:33]=[CH:32][C:31]([CH2:34][C@@H:35]([C:56]([O:58]C(C)(C)C)=[O:57])[NH:36][C:37]([C@@H:39]4[C:43]([CH3:45])([CH3:44])[S:42][CH2:41][N:40]4[S:46]([C:49]4[CH:54]=[CH:53][C:52]([CH3:55])=[CH:51][CH:50]=4)(=[O:48])=[O:47])=[O:38])=[CH:30][CH:29]=3)=[O:26])[CH2:21][CH2:20]2)=[O:18])=[CH:12][CH:11]=1)=[O:7])(C)(C)C>C(O)=O>[C:56]([C@@H:35]([NH:36][C:37]([C@@H:39]1[C:43]([CH3:44])([CH3:45])[S:42][CH2:41][N:40]1[S:46]([C:49]1[CH:50]=[CH:51][C:52]([CH3:55])=[CH:53][CH:54]=1)(=[O:48])=[O:47])=[O:38])[CH2:34][C:31]1[CH:32]=[CH:33][C:28]([O:27][C:25]([N:22]2[CH2:21][CH2:20][N:19]([C:17]([O:16][C:13]3[CH:12]=[CH:11][C:10]([CH2:9][C@@H:8]([C:6]([OH:7])=[O:5])[NH:63][C:64]([C@@H:66]4[C:70]([CH3:72])([CH3:71])[S:69][CH2:68][N:67]4[S:73]([C:76]4[CH:81]=[CH:80][C:79]([CH3:82])=[CH:78][CH:77]=4)(=[O:75])=[O:74])=[O:65])=[CH:15][CH:14]=3)=[O:18])[CH2:24][CH2:23]2)=[O:26])=[CH:29][CH:30]=1)([OH:58])=[O:57]

Participants

3

Reactant 1

HCID 86586593HCID 86586593, compound

Product 1

HCID 86586592HCID 86586592, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

The title compound was prepared by hydrolysis of the di-t-butyl ester from Example 299 with formic acid to give a white foam (300 mg, quantitative).

Workup

  1. customto give a white foam (300 mg, quantitative)

Sources & evidence

ORD record
ord-5e001edefee44571bc809800e4d18ec8
Source dataset
uspto-grants-2008_01
Patent number
US07320960B2

Reaction notes

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