HCID 69030337, compound → HCID 86596910, compound

Participants

Reaction Steps

The 7-amino-6-aza-oxindole 16 can also be prepared by lithiation of 2-fluoro-N,N-diisopropylnicotinamide 17 followed by quenching, such as with DMF, to give the 4-formyl-2-fluoro-N,N-diisopropylnicotinamide 18. The 4-formyl-2-fluoro-N,N-diisopropylnicotinamide can be reacted with an amine to give the 4-aminomethyl-2-fluoro-N,N-diisopropylnicotinamide 19 which can be reacted with another amine then cyclized under acidic conditions to afford the 7-amino-6-aza-oxindole 16.

Provenance & Evidence