4-Tert-Butylaniline → 2-(4-t-Butyl-phenyl)-7-hydroxy-2,3-dihydro-isoindol-1-one

HRID 2251843노트

반응식

HRID 2251843 반응식
C(O[C:4](=[O:14])[C:5]1[C:10]([OH:11])=[CH:9][CH:8]=[CH:7][C:6]=1[CH2:12]Br)C.[C:15]([C:19]1[CH:25]=[CH:24][C:22]([NH2:23])=[CH:21][CH:20]=1)([CH3:18])([CH3:17])[CH3:16]>CC(O)C>[C:15]([C:19]1[CH:20]=[CH:21][C:22]([N:23]2[CH2:12][C:6]3[C:5](=[C:10]([OH:11])[CH:9]=[CH:8][CH:7]=3)[C:4]2=[O:14])=[CH:24][CH:25]=1)([CH3:18])([CH3:16])[CH3:17]

참가 물질

4

반응물 2

HCID 698614-Tert-ButylanilineHCID 690310202-Bromomethyl-6-hydroxy-benzoic acid ethyl ester

생성물 1

HCID 690313142-(4-t-Butyl-phenyl)-7-hydroxy-2,3-dihydro-isoindol-1-one

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

2-Bromomethyl-6-hydroxy-benzoic acid ethyl ester (2.005 g), and 4-t-butylaniline (1.616 g) were put into 4 microwave reaction tubes along with 4.2 mL of iPrOH in each tube. The tubes were subjected to 170° C., 10 min of microwave. The resulting precipitate was collected via filtration and washed with iPrOH to obtain 2-(4-t-butyl-phenyl)-7-hydroxy-2,3-dihydro-isoindol-1-one as a white solid.

후처리

  1. filtrationThe resulting precipitate was collected via filtration
  2. washwashed with iPrOH

출처 및 근거

ORD 기록
ord-ea7f201a71b34788a070e1bfff03e639
출처 데이터셋
uspto-grants-2008_01
특허 번호
US07320992B2

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