HCID 55290937, compound → HCID 11235018, compound

Participants

Reaction Steps

Trifluoromethanesulfonic acid 2-(4-t-butyl-phenyl)-3-oxo-2,3-dihydro-1H-isoindol-4-yl ester (42 mg, Step A), (4-aminomethyl-pyrimidin-2-yl)-methyl-amine (19.2 mg), Pd(OAc)2 (3.4 mg), dppf (9.5 mg), CeCO3 (70 mg) and toluene (1 mL) were put into a microwave reaction tube and subjected to 120° C., for a total of 55 min of microwave. The solid was removed by filtration and solvent was evaporated. The resulting residue was purified by Gilson HPLC purification system to obtain 2-(4-t-butyl-phenyl)-7-[(2-methylamino-pyrimidin-4-ylmethyl)-amino]-2,3-dihydro-isoindol-1-one.

Provenance & Evidence