Hydrochloric Acid → 2-(4-Tert-butyl-phenyl)-4-fluoro-1-hydroxy-1,2-dihydro-pyrrolo[3,4-c]pyridin-3-one

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Reaction Conditions

Reaction Steps

To the solution of 2,2,6,6-tetramethylpiperidine (5.0 ml, 30.0 mmol) in 60 mL of anhydrous THF at −78° C. was added n-BuLi (2.5 M solution in hexanes, 16 mL, 40.0 mmol) under N2. The resulting mixture was stirred at −78° C. for 30 min, and a solution of N-(4-tert-butyl-phenyl)-2-fluoro-nicotinamide (2.72 g, 10.0 mmol, Step A) in 20 mL of THF was added dropwise. The mixture was stirred at −78° C. for 2 h, DMF (4.6 mL, 60.0 mmol) was added dropwise. The mixture was stirred at −78° C. for 30 min, then gradually warmed to RT. 1N HCl was added to bring pH to 2, then Na2CO3 was added to bring pH to 10. The mixture was extracted with EtOAc, the combined organic portions were dried with MgSO4, filtered, and condensed. The titled compound was obtained as a light-yellowish solid after column chromatography. MS (ES+): 301.2 (M+H)+. Calc'd for C17H17FN2O2-300.33.

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