反应详情

To a mixture of 2-(4-tert-butyl-phenyl)-4-fluoro-1-hydroxy-1,2-dihydro-pyrrolo[3,4-c]pyridin-3-one (0.085 g, 0.28 mmol, Step C) and triethylsilane (0.029 mL, 1.80 mmol) in 6 mL of CH2Cl2 was added TFA (0.62 mL, 7.80 mmol) at RT. The mixture was heated at reflux for 2 h, and the volatiles were removed under reduced pressure. The residue was purified by flash column chromatography (5 to 10% of EtOAc in CH2Cl2), to yield the titled compound as a white solid.

1. temperatureThe mixture was heated
2. temperatureat reflux for 2 h
3. customthe volatiles were removed under reduced pressure
4. customThe residue was purified by flash column chromatography (5 to 10% of EtOAc in CH2Cl2)