Methanol → 2-(Methoxycarbonyl)-3-nitrobenzoic acid

HRID 2251858Notes

Reaction equation

HRID 2251858 reaction equation
[N+:1]([C:4]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:5]=1[C:6](=[O:14])[O:7][C:8]2=[O:13])([O-:3])=[O:2].[CH3:15][OH:16]>>[CH3:15][O:16][C:6](=[O:14])[C:5]1[C:9](=[CH:10][CH:11]=[CH:12][C:4]=1[N+:1]([O-:3])=[O:2])[C:8]([OH:13])=[O:7]

Participants

3

Reactant 2

HCID 887MethanolHCID 216313-Nitrophthalic anhydride

Product 1

HCID 2430022-(Methoxycarbonyl)-3-nitrobenzoic acid

Procedure

4-Nitro-isobenzofuran-1,3-dione (10.0 g, 51.8 mmol) in 50 mL of anhydrous MeOH was heated to reflux under N2 overnight. The mixture was cooled to RT, poured into ice-cold water, and the precipitates were collected by filtration, then dried to give the titled compound as a white solid.

Workup

  1. temperatureto reflux under N2 overnight
  2. additionpoured into ice-cold water
  3. filtrationthe precipitates were collected by filtration
  4. customdried

Sources & evidence

ORD record
ord-89b26f498c1a4dbc9db5945ef07a3cf9
Source dataset
uspto-grants-2008_01
Patent number
US07320992B2

Reaction notes

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