HCID 69034312, compound → HCID 58588344, compound

HRID 2251869Notes

Reaction equation

HRID 2251869 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([CH:13]=[C:14]([C:16]([F:19])([F:18])[F:17])[CH:15]=1)[O:7][CH:8]1[CH2:12][CH2:11][O:10][CH2:9]1)([O-])=O>CO.[Pd]>[O:10]1[CH2:11][CH2:12][CH:8]([O:7][C:6]2[CH:5]=[C:4]([NH2:1])[CH:15]=[C:14]([C:16]([F:19])([F:18])[F:17])[CH:13]=2)[CH2:9]1

Participants

4

Reactant 1

HCID 69034312HCID 69034312, compound

Product 1

HCID 58588344HCID 58588344, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

The nitrobenzotrifluoride (Step B, 6.026 g, 21.7 mmol, 1 eq) was dissolved in MeOH (210 mL). 10% Pd/C (600 mg (10 wt %)) was carefully added to the reaction. The suspension was sparged with H2 and stirred under a H2 atm for 4 h. The mixture was filtered through a Celite® pad and the solvent removed in vacuo to yield the desired amine which was used without further purification.

Workup

  1. customThe suspension was sparged with H2
  2. filtrationThe mixture was filtered through a Celite® pad
  3. customthe solvent removed in vacuo

Sources & evidence

ORD record
ord-e8ab5beed834435f82f1c153908fa86e
Source dataset
uspto-grants-2008_01
Patent number
US07320992B2

Reaction notes

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