Nitrogen → HCID 69032420, compound

Participants

Reaction Steps

In a 100 mL round bottomed flask, 2-(4-tert-butyl-phenyl)-4-nitro-isoindole-1,3-dione (980 mg, 3.02 mmol) was dissolved in MeOH (30 mL). To this was added 10% Pd/C (100 mg) under a stream of N2. The flask was purged of oxygen and subjected to a balloon of H2 for 2 h. The reaction was filtered through a bed of Celite®, and the resulting filter cake was washed with EtOH. The filtrate was concentrated to a yellowish residue which was subjected to flash chromatography over silica gel eluting with 20% EtOAc in hexanes to give a yellow foam. MS (ES+): 295.2 (M+H)+.

Provenance & Evidence