1,4-Dioxane hydrochloride → (R)-3-Fluoro-5,11-dihydro-5-[1-(4-methoxyphenethyl)piperidin-2-yl-methyl]dibenzo[b,e][1,4]oxazepine hydrochloride

HRID 2251877Notes

Reaction equation

HRID 2251877 reaction equation
[ClH:1].O1CCOCC1.[F:8][C:9]1[CH:10]=[CH:11][C:12]2[CH2:18][O:17][C:16]3[CH:19]=[CH:20][CH:21]=[CH:22][C:15]=3[N:14]([CH2:23][C@H:24]3[CH2:29][CH2:28][CH2:27][CH2:26][N:25]3[CH2:30][CH2:31][C:32]3[CH:37]=[CH:36][C:35]([O:38][CH3:39])=[CH:34][CH:33]=3)[C:13]=2[CH:40]=1>ClCCl>[ClH:1].[F:8][C:9]1[CH:10]=[CH:11][C:12]2[CH2:18][O:17][C:16]3[CH:19]=[CH:20][CH:21]=[CH:22][C:15]=3[N:14]([CH2:23][C@H:24]3[CH2:29][CH2:28][CH2:27][CH2:26][N:25]3[CH2:30][CH2:31][C:32]3[CH:37]=[CH:36][C:35]([O:38][CH3:39])=[CH:34][CH:33]=3)[C:13]=2[CH:40]=1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 69198718(R)-3-fluoro-5,11-dihydro-5-[1-(4-methoxyphenethyl)piperidine-2-ylmethyl]dibenzo[b,e][1,4]oxazepine

Product 1

HCID 69200801(R)-3-Fluoro-5,11-dihydro-5-[1-(4-methoxyphenethyl)piperidin-2-yl-methyl]dibenzo[b,e][1,4]oxazepine hydrochloride

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

0.3 ml of 4 M hydrogen chloride/dioxane was added to a solution of (R)-3-fluoro-5,11-dihydro-5-[1-(4-methoxyphenethyl)piperidin-2-yl-methyl]dibenzo[b,e][1,4]oxazepine (300 mg, 0.7 mmol) in dichloromethane (5 ml), and they were stirred together for 30 minutes. The solvent was evaporated under reduced pressure. The obtained residue was solidified with a mixed solvent of hexane and ethyl acetate. The solid thus precipitated was taken by the filtration to obtain the title compound in the form of a brown solid (257 mg, 79%).

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. customThe solid thus precipitated
  3. filtrationwas taken by the filtration

Sources & evidence

ORD record
ord-d26b0276299a41a8a3212b3cc4d7f9a9
Source dataset
uspto-grants-2008_01
Patent number
US07320973B2

Reaction notes

Loading…