Ether hydrochloride → (R)-2-Fluoro-5,11-dihydro-5-[1-(4-pyrrolidinophenethyl)pyrrolidin-2-yl-methyl]dibenzo[b,e][1,4]oxazepine dihydrochloride

HRID 2251890Notes

Reaction equation

HRID 2251890 reaction equation
[ClH:1].C(OCC)C.[F:7][C:8]1[CH:41]=[CH:40][C:11]2[N:12]([CH2:21][C@H:22]3[CH2:26][CH2:25][CH2:24][N:23]3[CH2:27][CH2:28][C:29]3[CH:34]=[CH:33][C:32]([N:35]4[CH2:39][CH2:38][CH2:37][CH2:36]4)=[CH:31][CH:30]=3)[C:13]3[CH:20]=[CH:19][CH:18]=[CH:17][C:14]=3[O:15][CH2:16][C:10]=2[CH:9]=1>ClCCl>[ClH:1].[ClH:1].[F:7][C:8]1[CH:41]=[CH:40][C:11]2[N:12]([CH2:21][C@H:22]3[CH2:26][CH2:25][CH2:24][N:23]3[CH2:27][CH2:28][C:29]3[CH:30]=[CH:31][C:32]([N:35]4[CH2:36][CH2:37][CH2:38][CH2:39]4)=[CH:33][CH:34]=3)[C:13]3[CH:20]=[CH:19][CH:18]=[CH:17][C:14]=3[O:15][CH2:16][C:10]=2[CH:9]=1

Participants

4

Reactant 2

HCID 10953452Ether hydrochlorideHCID 59644017(R)-2-fluoro-5,11-dihydro-5-[1-(4-pyrrolidinophenethyl)pyrrolidin-2-ylmethyl]dibenzo[b,e][1,4]oxazepine

Product 1

HCID 69199662(R)-2-Fluoro-5,11-dihydro-5-[1-(4-pyrrolidinophenethyl)pyrrolidin-2-yl-methyl]dibenzo[b,e][1,4]oxazepine dihydrochloride

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

20 ml of 2 M hydrogen chloride/diethyl ether was added to a solution of (R)-2-fluoro-5,11-dihydro-5-[1-(4-pyrrolidinophenethyl)pyrrolidin-2-ylmethyl]dibenzo[b,e][1,4]oxazepine (2.29 g) in dichloromethane (30 ml), and they were stirred together for 2 hours. The solvent was evaporated under reduced pressure. The obtained residue was solidified by stirring it in hexane. The solid thus precipitated was taken by the filtration to obtain the title compound in the form of a brown solid (2.17 g, 81%).

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. stirringby stirring it in hexane
  3. customThe solid thus precipitated
  4. filtrationwas taken by the filtration

Sources & evidence

ORD record
ord-2d74ee5d69dc4e049fc1c5f8d437f749
Source dataset
uspto-grants-2008_01
Patent number
US07320973B2

Reaction notes

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