Ether hydrochloride → (r)-5,11-Dihydro-5-[1-(3-pyrrolidinophenethyl)pyrrolidin-2-ylmethyl]-dibenzo[b,e][1,4]oxazepine dihydrochloride

HRID 2251901Notes

Reaction equation

HRID 2251901 reaction equation
[ClH:1].C(OCC)C.[N:7]1([C:12]2[CH:13]=[C:14]([CH:38]=[CH:39][CH:40]=2)[CH2:15][CH2:16][N:17]2[CH2:21][CH2:20][CH2:19][C@@H:18]2[CH2:22][N:23]2[C:29]3[CH:30]=[CH:31][CH:32]=[CH:33][C:28]=3[CH2:27][O:26][C:25]3[CH:34]=[CH:35][CH:36]=[CH:37][C:24]2=3)[CH2:11][CH2:10][CH2:9][CH2:8]1>ClCCl>[ClH:1].[ClH:1].[N:7]1([C:12]2[CH:13]=[C:14]([CH:38]=[CH:39][CH:40]=2)[CH2:15][CH2:16][N:17]2[CH2:21][CH2:20][CH2:19][C@@H:18]2[CH2:22][N:23]2[C:29]3[CH:30]=[CH:31][CH:32]=[CH:33][C:28]=3[CH2:27][O:26][C:25]3[CH:34]=[CH:35][CH:36]=[CH:37][C:24]2=3)[CH2:11][CH2:10][CH2:9][CH2:8]1

Participants

4

Reactant 2

HCID 10953452Ether hydrochlorideHCID 12990604(r)-5,11-Dihydro-5-[1-(3-pyrrolidinophenethyl)pyrrolidin-2-ylmethyl]dibenzo[b,e][1,4]oxazepine

Product 1

HCID 69201019(r)-5,11-Dihydro-5-[1-(3-pyrrolidinophenethyl)pyrrolidin-2-ylmethyl]-dibenzo[b,e][1,4]oxazepine dihydrochloride

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2.0 ml of 2 M hydrogen chloride/diethyl ether was added to a solution of (R)-5,11-dihydro-5-[1-(3-pyrrolidinophenethyl)pyrrolidin-2-ylmethyl]dibenzo[b,e][1,4]oxazepine (208 mg) in dichloromethane (2 ml), and they were stirred together for 2 hours. The solvent was evaporated under reduced pressure. The obtained residue was solidified by stirring it in hexane. The solid thus precipitated was taken by the filtration to obtain the title compound in the form of a light brown solid (220 mg, 91%).

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. stirringby stirring it in hexane
  3. customThe solid thus precipitated
  4. filtrationwas taken by the filtration

Sources & evidence

ORD record
ord-3e3623e7f1c44c4aa5e093cb67b95be7
Source dataset
uspto-grants-2008_01
Patent number
US07320973B2

Reaction notes

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