Isopropanol hydrochloride → (R)-2-Fluoro-5,11-dihydro-5-[1-(4-pyrrolidinophenethyl)pyrrolidin-2-yl-methyl]dibenzo[b,e][1,4]oxazepine dihydrochloride

Participants

Reaction Steps

(R)-2-Fluoro-5,11-dihydro-5-[1-(4-pyrrolidinophenethyl)pyrrolidin-2-ylmethyl]dibenzo[b,e][1,4]oxazepine (12.04 g, 25.5 mmol) was dissolved in 2-propanol (250 ml). 4 M hydrogen chloride/2-propanol (17.0 ml) was added to the obtained solution and they were stirred at room temperature for 0.5 hour. The solvent was evaporated under reduced pressure, and 2-propanol (about 50 ml) was added to the residue. The solvent was evaporated under reduced pressure repeatedly 4 times to obtain the title compound in the form of a light red solid (14.89 g, 100%).

Provenance & Evidence