Hydrazine → HCID 15586932, compound

Participants

Reaction Conditions

Reaction Steps

5 g (0.0146 moles) of 6-methyl-8β-mesyloxymethyl-ergoline are suspended in 25 ml of dry hydrazine distilled from sodium hydroxide. The suspension is refluxed under a nitrogen atmosphere on an oil bath heated to 150° C. for 20 minutes after the complete dissolution of the solids. In this operation atmospheric moisture should be excluded carefully. The mixture is cooled and allowed to stand in a refrigerator. The separated crystals are filtered off, washed with water, and then dried in vacuo. 2.8 g (71%) of 6-methyl-8β-hydrazinomethyl-ergoline are obtained; m.p.: 171°-172° C., [α]D20 =-62.8° (c=0.2, in tetrahydrofuran).

Provenance & Evidence