HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus pentachloride → 5-chloro-1-(3,5-dichloro-benzyl)-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus pentachloride | HCID 24819 | — |
| Reactant | HCID 178470507 | HCID 178470507 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 5-chloro-1-(3,5-dichloro-benzyl)-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester | HCID 69123647 | — |
Reaction Steps
Combine 1-(3,5-Dichloro-benzyl)-5-hydroxy-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester (1 eq) with PCl5 (2 eq) in toluene and heat at 40-50° C. until reaction is complete. Concentrate the mixture, treat with aqueous NaHCO3, and extract with Et2O. Dry the combined extracts over Na2SO4, concentrate, and purify by chromatography on silica gel. MS (IS) 334.0, 336.0 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07320994B2 |
| Source dataset | uspto-grants-2008_01 |
| ORD ID | ord-1b09857a33c3424eaede852673ec2ecb |
| Source note | uspto-grants-2008_01 |