Morpholine → HCID 59644534, compound

Participants

Reaction Conditions

Reaction Steps

Dissolve {5-[1-(3,5-bis-trifluoromethyl-benzyl)-5-chloro-1H-[1,2,3]triazol-4-yl]-3-hydroxymethyl-isoxazol-4-yl}-(2-chloro-phenyl)-methanone (0.10 g, 018 mmol) in morpholine (1.0 mL) and stir at 80° C. for 20 hours. Dilute the solution with EtOAc (25 mL) and wash with 1N HCl (20 mL), water (20 mL), and saturated NaHCO3 (20 mL) then dry, filter, and concentrate. Purify the crude material by flash chromatography to give the title compound: MS (IS) 615.9 (M+1), MS (ES−) 613.9 (M−1): 1HNMR (400 MHz, CDCl3) δ 7.95 (s, 1H), 7.74 (s, 2H), 7.45 (dd, 1H, J=1.4, 7.5), 6.93 (dt, 1H, J=1.5, 7.4), 6.83 (dt, 1H, J=1.0, 7.4), 6.40 (m, 1H), 5.42 (s, 2H), 4.85 (d, 2H, J=7.3), 3.80 (t, 1H, J=7.3), 3.44 (m, 4H), 2.64 (m, 4H).

Provenance & Evidence