Ammonium Chloride → HCID 86601258, compound

Participants

Reaction Conditions

Reaction Steps

Dissolve [5-[1-(3,5-bis-trifluoromethyl-benzyl)-5-dimethylamino-1H-[1,2,3]triazol-4-yl]-4-(2-chloro-4-fluoro-benzyl)-4H-[1,2,4]triazol-3-yl]-acetic acid ethyl ester (338 mg) in THF (5 mL). Cool to 0° C., add 2M LiBH4 (0.8 mL, 2M soln in THF) and stir overnight while slowly warming to RT. Pour reaction into aqueous NH4Cl (15 mL) and extract with EtOAc (2×15 mL). Purify via radial chromatography using a gradient of 1:1 to 1:5 hexanes:EtOAc to give the title compound (137 mg, 44%). MS (IS) 592.0 (M+1); Rf=0.11 (1:5 hexanes:EtOAc).

Provenance & Evidence