Aluminium lithium hydride → HCID 59644535, compound

Participants

Reaction Steps

Dissolve [5-[1-(3,5-bis-trifluoromethyl-benzyl)-5-phenyl-1H-[1,2,3]triazol-4-yl]-4-(2-chloro-benzyl)-4H-[1,2,4]triazol-3-yl]-acetic acid ethyl ester (400 mg) in THF (10 mL). Add LAH (47 mg, soln in 10 mL of THF) at 0° C. and warm to RT overnight. Quench by slowly adding water (0.5 ml), 5N NaOH (0.5 ml) and then more water (3 ml). Filter reaction through Celite® to remove aluminum salts and then purify via radial chromatography using a gradient of 1:1 hexanes:EtOAc to 100% EtOAc to give the title compound (119 mg, 32%). MS (IS) 592.0 (M+1). Rf=0.11 (1:5 hexanes:EtOAc).

Provenance & Evidence