HCID 59644552, compound → HCID 59644533, compound

HRID 2252012Notes

Reaction equation

HRID 2252012 reaction equation
[F:1][C:2]([F:39])([F:38])[C:3]1[CH:4]=[C:5]([CH:31]=[C:32]([C:34]([F:37])([F:36])[F:35])[CH:33]=1)[CH2:6][N:7]1[C:11]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[C:10]([C:18]2[N:19]([CH2:23][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=3[Cl:30])[CH2:20][CH2:21][N:22]=2)[N:9]=[N:8]1>[Pd]>[F:39][C:2]([F:1])([F:38])[C:3]1[CH:4]=[C:5]([CH:31]=[C:32]([C:34]([F:35])([F:36])[F:37])[CH:33]=1)[CH2:6][N:7]1[C:11]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[C:10]([C:18]2[N:19]([CH2:23][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=3[Cl:30])[CH:20]=[CH:21][N:22]=2)[N:9]=[N:8]1

Participants

3

Reactant 1

HCID 59644552HCID 59644552, compound

Product 1

HCID 59644533HCID 59644533, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Conditions

Temperature
137 °C

Procedure

To a solution of 1-(3,5-bis-trifluoromethyl-benzyl)-4-[1-(2-chloro-benzyl)-4,5-dihydro-1H-imidazol-2-yl]-5-phenyl-1H-[1,2,3]triazole (300 mg, 0.53 mmol) in xylenes (2.66 mL) add 10% Pd/C (300 mg). Heat to 137° C. After 72 hours, cool reaction, filter, and concentrate. Purify by chromatography using a gradient of 50:1 to 10:1 CHCl3/MeOH to afford the title compound: MS (IS) 562.0 (M+1).

Workup

  1. temperaturecool
  2. customreaction
  3. filtrationfilter
  4. concentrationconcentrate
  5. customPurify by chromatography

Sources & evidence

ORD record
ord-a04a02ba91554fb69b28cf3672da2f10
Source dataset
uspto-grants-2008_01
Patent number
US07320994B2

Reaction notes

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