HCID 10175375, compound → HCID 87716473, compound

Participants

Reaction Steps

Dissolve {4-amino-2-[1-(3,5-bistrifluoromethylbenzyl)-5-phenyl-1H-[1,2,3]triazol-4-yl]-pyridin-3-yl}-(2-chlorophenyl)-methanone (582 g, 0.97 mol) in ethyl acetate (1880 mL), heptane (1990 mL) and water (90 mL) at 70° C. Cool to room temperature and stir for 18.5 hours. Add heptane (3980 mL) dropwise over 4 hours. Filter and dry in a vacuum oven at 40° C. for approximately 15 hours to give the title compound. Kf=1.52%.

Provenance & Evidence