HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Iodide → HCID 19002669, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 3,5-Difluorophenol | HCID 75928 | — |
| Reactant | HCID 17981832 | HCID 17981832 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 19002669 | HCID 19002669 | 50% |
Reaction Steps
Add pyrrolidin-1-yl-ethanol hydrochloride (1.5 g) to a mixture of 3,5-difluorophenol (1.0 g), cesium carbonate (8.78 g), sodium iodide (1.15 g) in dry dimethylformamide (20 mL). Stir at room temperature overnight. Concentrate under reduced pressure and the residue is purified by chromatography eluting with ethyl acetate:hexane (1:1) to provide (0.8 g, 50%) of an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07320995B2 |
| Source dataset | uspto-grants-2008_01 |
| ORD ID | ord-9a702cca235046c0b70edeff95e0ca90 |
| Source note | uspto-grants-2008_01 |