Tetrahydrofuran → HCID 85937151, compound

Participants

Reaction Steps

Cool a mixture of 1-(3,5-difluoro-phenoxymethyl)-pyrrolidine (0.1 g) and dry tetrahydrofuran (5 mL) to −78° C. under a nitrogen atmosphere. Add butyllithium (0.29 mL, 1.6 M in tetrahydrofuran) and N,N,N′,N′-tetramethylethylenediamine (0.5 mL) and stir for 30 minutes. Then, add dimethylformamide (0.07 mL) and stir at room temperature for 60 minutes. Quench by pouring the reaction mixture into a mixture of cold saturated aqueous ammonium chloride and ethyl acetate. Separate the layers, wash the organic phase with water and then concentrate under reduced pressure to provide (0.10 g, 94%) of the title compound as an oil.

Provenance & Evidence