Ethyl 1H-pyrrole-2-carboxylate → HCID 67281814, compound

HRID 2252128Notes

Reaction equation

HRID 2252128 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[CH2:5]2.[CH2:12]([N:14]([CH2:27][CH3:28])[CH2:15][CH2:16][NH:17][C:18]([C:20]1[NH:21][C:22]([CH:25]=O)=[CH:23][CH:24]=1)=[O:19])[CH3:13].N1C=CC=C1C(OCC)=O>>[CH2:27]([N:14]([CH2:12][CH3:13])[CH2:15][CH2:16][NH:17][C:18]([C:20]1[NH:21][C:22]([CH:25]=[C:5]2[C:4]3[C:8](=[CH:9][CH:10]=[C:2]([Br:1])[CH:3]=3)[NH:7][C:6]2=[O:11])=[CH:23][CH:24]=1)=[O:19])[CH3:28]

Participants

4

Reactant 3

HCID 255670Ethyl 1H-pyrrole-2-carboxylateHCID 6111935-Bromo-2-oxindoleHCID 85786882HCID 85786882, compound

Product 1

HCID 67281814HCID 67281814, compoundYield 38%

Procedure

5-Bromo-1,3-dihydroindol-2-one (212 mg, 1 mmol) was condensed with 5-formyl-1H-pyrrole-2-carboxylic acid (2-diethylaminoethyl)amide (prepared from ethyl pyrrole-2-carboxylate by method A, B and then C) to give 162 mg (38%) of the title compound.

Sources & evidence

ORD record
ord-d8cc95e9553b40808ac3cceca1632cfb
Source dataset
uspto-grants-2008_01
Patent number
US07320996B2

Reaction notes

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