5-Bromo-2-oxindole → HCID 67281963, compound

HRID 2252137Notes

Reaction equation

HRID 2252137 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[CH2:5]2.[CH2:12]([N:14]([CH2:31][CH3:32])[CH2:15][CH2:16][NH:17][C:18]([C:20]1[NH:21][C:22]([CH:29]=O)=[C:23]2[C:28]=1[CH2:27][CH2:26][CH2:25][CH2:24]2)=[O:19])[CH3:13]>>[CH2:31]([N:14]([CH2:12][CH3:13])[CH2:15][CH2:16][NH:17][C:18]([C:20]1[NH:21][C:22]([CH:29]=[C:5]2[C:4]3[C:8](=[CH:9][CH:10]=[C:2]([Br:1])[CH:3]=3)[NH:7][C:6]2=[O:11])=[C:23]2[C:28]=1[CH2:27][CH2:26][CH2:25][CH2:24]2)=[O:19])[CH3:32]

Participants

3

Reactant 2

HCID 6111935-Bromo-2-oxindoleHCID 86586198HCID 86586198, compound

Product 1

HCID 67281963HCID 67281963, compoundYield 67%

Procedure

5-Bromo-1,3-dihydroindol-2-one (1.43 g, 6.8 mmol) was condensed with 3-formyl-4,5,6,7-tetrahydro-2H-isoindole-1-carboxylic acid (2-diethylaminoethyl)amide (1.97 g) to give 2.2 g (67%) of the title compound as a yellow-orange solid.

Sources & evidence

ORD record
ord-523b679db9df4637a97de49c4196a52a
Source dataset
uspto-grants-2008_01
Patent number
US07320996B2

Reaction notes

Loading…