5-Bromo-2-oxindole → HCID 67282596, compound

HRID 2252138Notes

Reaction equation

HRID 2252138 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[CH2:5]2.[N:12]1([CH2:17][CH2:18][CH2:19][NH:20][C:21]([C:23]2[NH:24][C:25]([CH:32]=O)=[C:26]3[C:31]=2[CH2:30][CH2:29][CH2:28][CH2:27]3)=[O:22])[CH2:16][CH2:15][CH2:14][CH2:13]1>>[N:12]1([CH2:17][CH2:18][CH2:19][NH:20][C:21]([C:23]2[NH:24][C:25]([CH:32]=[C:5]3[C:4]4[C:8](=[CH:9][CH:10]=[C:2]([Br:1])[CH:3]=4)[NH:7][C:6]3=[O:11])=[C:26]3[C:31]=2[CH2:30][CH2:29][CH2:28][CH2:27]3)=[O:22])[CH2:16][CH2:15][CH2:14][CH2:13]1

Participants

3

Reactant 2

HCID 6111935-Bromo-2-oxindoleHCID 86586200HCID 86586200, compound

Product 1

HCID 67282596HCID 67282596, compoundYield 22%

Procedure

5-Bromo-1,3-dihydroindol-2-one (80 mg, 0.4 mmol) was condensed with 3-formyl-4,5,6,7-tetrahydro-2H-isoindole-1-carboxylic acid (3-pyrrolidin-1-ylpropyl)amide (120 mg) to give 43 mg (22%) of the title compound as a tan-orange solid.

Sources & evidence

ORD record
ord-118e38c039344aa8b0d93d2fe02a72be
Source dataset
uspto-grants-2008_01
Patent number
US07320996B2

Reaction notes

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