1-Pyrrolidinepropanamine → HCID 67281014, compound

HRID 2252146Notes

Reaction equation

[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[C:5]2=[CH:12][C:13]1[NH:17][C:16]([CH:18]([CH3:20])[CH3:19])=[C:15]([C:21](O)=[O:22])[C:14]=1[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1.[N:30]1([CH2:35][CH2:36][CH2:37][NH2:38])[CH2:34][CH2:33][CH2:32][CH2:31]1>>[N:30]1([CH2:35][CH2:36][CH2:37][NH:38][C:21]([C:15]2[C:14]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)=[C:13]([CH:12]=[C:5]3[C:4]4[C:8](=[CH:9][CH:10]=[C:2]([Br:1])[CH:3]=4)[NH:7][C:6]3=[O:11])[NH:17][C:16]=2[CH:18]([CH3:20])[CH3:19])=[O:22])[CH2:34][CH2:33][CH2:32][CH2:31]1

Participants

Reactant 2

HCID 316701-Pyrrolidinepropanamine

HCID 67281636HCID 67281636, compound

Product 1

HCID 67281014HCID 67281014, compoundYield 89%

Procedure

5-(5-bromo-2-oxo-1,2-dihydroindol-3-ylidenemethyl)-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid (127 mg, 0.28 mmol) was condensed with 3-pyrrolidin-1-yl-propylamine (43 mg, 0.336 mmol) to give 140 mg (66%) of the title compound.

Sources & evidence

ORD record: ord-4b75123894084b9f867e078f37d07190
Source dataset: uspto-grants-2008_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07320996B2

Reaction notes

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