5-Bromo-2-oxindole → HCID 67280999, compound

HRID 2252148Notes

Reaction equation

HRID 2252148 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[CH2:5]2.[CH3:12][N:13]1[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][CH2:21][NH:22][C:23]([C:25]2[C:29]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)=[C:28]([CH:36]=O)[NH:27][C:26]=2[CH:38]([CH3:40])[CH3:39])=[O:24])[CH2:15][CH2:14]1>>[CH3:12][N:13]1[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][CH2:21][NH:22][C:23]([C:25]2[C:29]([C:30]3[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=3)=[C:28]([CH:36]=[C:5]3[C:4]4[C:8](=[CH:9][CH:10]=[C:2]([Br:1])[CH:3]=4)[NH:7][C:6]3=[O:11])[NH:27][C:26]=2[CH:38]([CH3:40])[CH3:39])=[O:24])[CH2:15][CH2:14]1

Participants

3

Reactant 2

HCID 6111935-Bromo-2-oxindoleHCID 86586204HCID 86586204, compound

Product 1

HCID 67280999HCID 67280999, compoundYield 44%

Procedure

5-Bromo-1,3-dihydroindol-2-one (53 mg, 0.25 mmol) was condensed with 5-formyl-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid [3-(4-methylpiperazin-1-yl)propyl]amide (300 mg) to give 65 mg of the title compound.

Sources & evidence

ORD record
ord-0ff601867a0142f8a7cdd3a9d4a49589
Source dataset
uspto-grants-2008_01
Patent number
US07320996B2

Reaction notes

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