5-Bromo-2-oxindole → HCID 67281072, compound

HRID 2252181Notes

Reaction equation

HRID 2252181 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[CH2:5]2.[CH2:12]([N:14]([CH2:34][CH3:35])[CH2:15][CH2:16][CH2:17][NH:18][C:19]([C:21]1[C:25]([CH:26]([CH3:28])[CH3:27])=[C:24]([CH:29]=O)[NH:23][C:22]=1[CH:31]([CH3:33])[CH3:32])=[O:20])[CH3:13]>>[CH2:34]([N:14]([CH2:12][CH3:13])[CH2:15][CH2:16][CH2:17][NH:18][C:19]([C:21]1[C:25]([CH:26]([CH3:28])[CH3:27])=[C:24]([CH:29]=[C:5]2[C:4]3[C:8](=[CH:9][CH:10]=[C:2]([Br:1])[CH:3]=3)[NH:7][C:6]2=[O:11])[NH:23][C:22]=1[CH:31]([CH3:33])[CH3:32])=[O:20])[CH3:35]

Participants

3

Reactant 2

HCID 6111935-Bromo-2-oxindoleHCID 86586211HCID 86586211, compound

Product 1

HCID 67281072HCID 67281072, compoundYield 25%

Procedure

5-Bromo-1,3-dihydroindol-2-one (90 mg, 0.42 mmol) was condensed with 5-formyl-2,4-diisopropyl-1H-pyrrole-3-carboxylic acid (3-diethylaminopropyl)amide (140 mg) to give 54 mg (25%) of the title compound as red-brown solid.

Sources & evidence

ORD record
ord-20694a78c132484abf96d89dcd5f213d
Source dataset
uspto-grants-2008_01
Patent number
US07320996B2

Reaction notes

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