5-Bromo-2-oxindole → HCID 67280990, compound

HRID 2252182Notes

Reaction equation

HRID 2252182 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[CH2:5]2.[N:12]1([CH2:17][CH2:18][CH2:19][NH:20][C:21]([C:23]2[C:27]([CH:28]([CH3:30])[CH3:29])=[C:26]([CH:31]=O)[NH:25][C:24]=2[CH:33]([CH3:35])[CH3:34])=[O:22])[CH2:16][CH2:15][CH2:14][CH2:13]1>>[N:12]1([CH2:17][CH2:18][CH2:19][NH:20][C:21]([C:23]2[C:27]([CH:28]([CH3:30])[CH3:29])=[C:26]([CH:31]=[C:5]3[C:4]4[C:8](=[CH:9][CH:10]=[C:2]([Br:1])[CH:3]=4)[NH:7][C:6]3=[O:11])[NH:25][C:24]=2[CH:33]([CH3:35])[CH3:34])=[O:22])[CH2:16][CH2:15][CH2:14][CH2:13]1

Participants

3

Reactant 2

HCID 6111935-Bromo-2-oxindoleHCID 86586212HCID 86586212, compound

Product 1

HCID 67280990HCID 67280990, compoundYield 15.2%

Procedure

5-Bromo-1,3-dihydroindol-2-one (130 mg, 0.6 mmol) was condensed with 5-formyl-2,4-diisopropyl-1H-pyrrole-3-carboxylic acid (3-pyrrolidin-1-ylpropyl)amide (150 mg, 0.45 mmol) to give 36 mg (15%) of the title compound as a tan-orange solid.

Sources & evidence

ORD record
ord-4b2687606e90492688c576dca4a3c1b8
Source dataset
uspto-grants-2008_01
Patent number
US07320996B2

Reaction notes

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