5-Bromo-2-oxindole → HCID 67282339, compound

HRID 2252183Notes

Reaction equation

HRID 2252183 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[CH2:5]2.[N:12]1[CH:17]=[CH:16][C:15]([CH2:18][NH:19][C:20]([C:22]2[C:26]([CH3:27])=[C:25]([CH:28]=O)[NH:24][C:23]=2[CH3:30])=[O:21])=[CH:14][CH:13]=1>>[N:12]1[CH:13]=[CH:14][C:15]([CH2:18][NH:19][C:20]([C:22]2[C:26]([CH3:27])=[C:25]([CH:28]=[C:5]3[C:4]4[C:8](=[CH:9][CH:10]=[C:2]([Br:1])[CH:3]=4)[NH:7][C:6]3=[O:11])[NH:24][C:23]=2[CH3:30])=[O:21])=[CH:16][CH:17]=1

Participants

3

Reactant 2

HCID 6111935-Bromo-2-oxindoleHCID 85786886HCID 85786886, compound

Product 1

HCID 67282339HCID 67282339, compoundYield 4%

Procedure

5-Bromo-1,3-dihydroindol-2-one (170 mg, 0.8 mmol) was condensed with 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (pyridin-4-ylmethyl)amide (200 mg) to give 14 mg (4%) of the title compound as a yellow solid.

Sources & evidence

ORD record
ord-b37aef73f02241388ea2b361a4b2b3f2
Source dataset
uspto-grants-2008_01
Patent number
US07320996B2

Reaction notes

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