HCID 136343326, compound → HCID 136337756, compound

Participants

Reaction Steps

A mixture of Example 134D (23.0 mg, 0.0497 mmol) and HCl (concentrated, 2 drops) in EtOH (2 mL) was stirred at 75° C. for 1.5 hours. The solvent was evaporated and the residue was purified using reversed-phase HPLC to give the desired product (4.0 mg) as TFA salt. MS (ESI) m/z: 333.0 (M+H)+; 1H NMR (300 MHz, CD3OD) δ ppm 1.56 (s, 6H) 3.93 (s, 3H) 6.94 (s, 1H) 7.20 (s, 1H) 7.99 (d, J=8.14 Hz, 1H) 8.32 (dd, J=8.14, 2.37 Hz, 1H) 9.11 (d, J=2.37 Hz, 1H).

Provenance & Evidence