Potassium Iodide → HCID 58585386, compound

Participants

Reaction Steps

1.35 ml (18.11 mmol) of 2-bromoethanol are added dropwise to a mixture of 4.18 (9.05 mmol) of 4-(4-bromophenoxy)-2-(4-chlorophenyl)-5-(1-piperazinyl)-3(2H)-pyridazinone (Example 57A), 0.15 g of potassium iodide 3.75 g (27.2 mmol) of potassium carbonate in 25 ml of 1,4-dioxane. Stirring under reflux overnight is followed by dilution with dichloromethane and washing twice with water, drying and concentration. Purification is by flash chromatography on silica gel (gradient: dichloromethane/methanol from 99:1 to 97:3).

Provenance & Evidence