1,2-Dichloroethane → HCID 86602431, compound

Participants

Reaction Conditions

Reaction Steps

160 mg (0.348 mmol) of the compound from Example 12, dissolved in 1 ml of dichloromethane, are added dropwise to a solution of 92 mg (0.487 mmol) of Boc-L-alanine, 93.4 mg (0.487 mmol) of EDC, 65.8 mg (0.487 mmol) of HOBt and 0.1 ml (0.717 mmol) of triethylamine in 2 ml of tetrahydrofuran and 10 ml of dichloromethane while stirring under argon at 0° C. The mixture is stirred at room temperature overnight. The reaction solution is diluted with 100 ml of dichloromethane, washed with saturated sodium bicarbonate solution and brine, dried over sodium sulfate and concentrated. The residue is stirred with ether and filtered off with suction.

Provenance & Evidence