Phosphorus oxychloride → HCID 59215154, compound

Participants

Reaction Conditions

Reaction Steps

POCl3 (3 mL) was added to 7-(4-methoxyphenyl)-2-trifluoromethyl-[1,6]naphthyridin-5-ol (Example 19) (125 mg, 0.4 mmol). The mixture was heated at 100° C. for 3 hours. The excess POCl3 was concentrated under reduced pressure. The residue was diluted with CH2Cl2, washed with sat. NaHCO3, dried over Na2SO4, and concentrated giving the title compound (73 mg, 55%) as an orange solid.

Provenance & Evidence