Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Benzylamine | HCID 7504 | — |
| Reactant | HCID 59215152 | HCID 59215152 | — |
| Solvent | 1-Methoxyethanol | HCID 3015637 | — |
| Product | HCID 59215167 | HCID 59215167 | 30.5% |
Reaction Steps
2,5-Dichloro-7-(4-methoxyphenyl)-[1,6]naphthyridine (147 mg, 0.48 mmol) and benzyl amine (0.055 mL, 0.5 mmol) were combined in methoxyethanol (2 mL) and stirred at 80° C. for 72 hours. The crude reaction mixture was concentrated, and column chromatography afforded benzyl-[5-chloro-7-(4-methoxyphenyl)-[1,6]naphthyridin-2-yl]-amine (55 mg, 30%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07321041B2 |
|---|
| Source dataset | uspto-grants-2008_01 |
|---|
| ORD ID | ord-1d24134689e94aa0ba139abfcf44d078 |
|---|
| Source note | uspto-grants-2008_01 |
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