Hydrazine → 5-Bromo-2-hydrazinopyridine

Participants

Reaction Conditions

Reaction Steps

A mixture of 2,5-Dibromo-pyridine (13 g, 55.1 mmol) and hydrazine (13 mL, 414 mmol) in pyridine (13 mL) was heated at 85° C. for 48 hours. The reaction was cooled and concentrated in vacuo. The residue was triturated in 1N NaOH (20 mL) and toluene (20 mL). The solid was filtered, washed with water, and dried to give the above named compound (6.43 g, 62%).

Provenance & Evidence