Ethyl isocyanate → HCID 9842281, compound

HRID 2252326Notes

Reaction equation

HRID 2252326 reaction equation
[CH:1]([C:4]1[N:8]2[CH:9]=[C:10]([S:13][C:14]3[CH:21]=[CH:20][CH:19]=[CH:18][C:15]=3[CH2:16][NH2:17])[CH:11]=[CH:12][C:7]2=[N:6][N:5]=1)([CH3:3])[CH3:2].[CH2:22]([N:24]=[C:25]=[O:26])[CH3:23]>ClCCl>[CH2:22]([NH:24][C:25]([NH:17][CH2:16][C:15]1[CH:18]=[CH:19][CH:20]=[CH:21][C:14]=1[S:13][C:10]1[CH:11]=[CH:12][C:7]2[N:8]([C:4]([CH:1]([CH3:3])[CH3:2])=[N:5][N:6]=2)[CH:9]=1)=[O:26])[CH3:23]

Participants

4

Reactant 2

HCID 8022Ethyl isocyanateHCID 17974505HCID 17974505, compound

Product 1

HCID 9842281HCID 9842281, compoundYield 94%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 2-(3-Isopropyl-[1,2,4]triazolo[4,3-a]pyridin-6-ylsulfanyl)-benzylamine (200.0 mg, 0.671 mmol) in dichloromethane (6.71 mL) under nitrogen at ambient temperature was added ethyl isocyanate (53.0 μL, 0.67 mmol). The reaction was stirred for 20 minutes, then the solvent was removed in vacuo. The residue was recrystallized from ethyl acetate to give the title compound (231 mg, 94%). MS (M+1)=370.5.

Workup

  1. customthe solvent was removed in vacuo
  2. customThe residue was recrystallized from ethyl acetate

Sources & evidence

ORD record
ord-177e5d2a765247f5894fa8b6ce304fa9
Source dataset
uspto-grants-2008_01
Patent number
US07321040B2

Reaction notes

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