Ethyl isocyanate → HCID 10474323, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of [2-(3-Isopropyl-[1,2,4]triazolo[4,3-a]pyridin-6-ylsulfanyl)-phenyl]-methanol (45.0 mg, 0.15 mmol) in dichloromethane (1.5 mL) under nitrogen at ambient temperature was added ethyl isocyanate (12.0 μL, 0.15 mmol). The reaction was heated to 50° C. for 1 hour. The reaction was cooled, ethyl isocyanate added (30 μL, 0.38 mmol), and stirred at ambient temperature for 16 hours. The reaction was concentrated in vacuo to an oil. The residue was triturated from ether to give the title compound (45 mg, 82%). MS (M+1)=371.4.

Provenance & Evidence