Potassium Carbonate → HCID 17974502, compound

Participants

Reaction Steps

A mixture of 6-chloro-pyridin-3-ol (418 mg, 3.2 mmol), 2-fluorobenzaldehyde (522 mg, 4.21 mmol), potassium carbonate (442 mg, 3.2 mmol) and copper powder (201 mg, 3.2 mmol) was heated in DMF (6.4 mL) at 120° C. for 6 hours. The reaction was then cooled, and concentrated to an oil. The residue was purified by flash chromatography (eluting with 20% ethyl acetate/hexane) to give the title compound as a brown solid (700 mg, 93%).

Provenance & Evidence