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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2252383Generated: November 1, 2026

1-(Bromomethyl)-4-(trifluoromethoxy)benzene → HCID 69300297, compound

https://huagongshe.com/reaction/2252383

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(Bromomethyl)-4-(trifluoromethoxy)benzeneHCID 142785—
ReactantHCID 69300313HCID 69300313—
ProductHCID 69300297HCID 69300297100%

Reaction Steps

In a manner similar to the method described in Example 36-2, using 281 mg of 1-(3-benzyloxy-17-cyclopropylmethyl-4,5α-epoxy-14-hydroxy-morphinan-6α-yl)-pyrrolidin-2-one obtained in Example 36-1, and using 4-trifluoromethoxybenzyl bromide in place of iodoethane, 383 mg (yield: 100%) of the captioned compound was obtained as a diastereomer mixture.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07320984B2
Source datasetuspto-grants-2008_01
ORD IDord-5e50101178b84fcd831baaf58de55ca8
Source noteuspto-grants-2008_01